3 Ways to Increase DNA Methylation and Get Biologically Younger

When you increase DNA methylation, you take a big step to improving your healthspan by decreasing your bioage relative to your chronological age. The science on this is pretty definitive, so let’s dive in to learn about DNA methylation, its influence on the aging process and the three ways you can increase DNA methylation.

3 Ways to Increase DNA Methylation

DNA Methylation | Stop DNA From Aging With TMG by Dr Brad Stanfield

As you’ll soon see, the scientific evidence suggests that if you increase DNA methylation, you’ll increase your healthspan, because by increasing your DNA methylation, you can reduce your biological age.

That’s what this post is about; namely:

  • First, we’ll define DNA methylation and examine how it influences how you age;
  • Then how to measure your biological age via DNA methylation; and
  • Finally, a look at three ways you can increase DNA methylation.

In all this, we’re guided by a video made by Dr. Brad Stanfield, a young medical doctor who moonlights as an anti-aging guru on his Youtube channel.

Let’s go!


DNA Methylation Strongly Influences How You Age

Increase DNA methylation to age better

DNA is a molecule composed of two polynucleotide chains that coil around each other to form a double helix carrying genetic instructions for the development, functioning, growth and reproduction of all known organisms and many viruses.

It’s a code for our cells that gives them specific instructions based on its genetic information that is carried from cell to cell, and from generation to generation. Thus a major function of DNA is to store genetic information.

Within the cells are proteins. DNA codes those proteins, one of which are our genes. These genes are under tight control — we don’t want to create too many or too few of them — and the process that controls this particular DNA expression is called “DNA methylation”.

Basically, DNA methylation is the process whereby a methyl group binds to DNA. The methyl group comes from a molecule called “S-adenylyl methionine”. When these methyl groups bind to DNA, they switch off those genes: DNA methylation “silences” the gene’s expression; meaning, it determines what any particular cell can do.

If methylation levels are boosted, it switches off genes; whereas if we’ve got too little DNA methylation then it switches on the genes.

The key takeaway here is that methylation controls our DNA. This can be good or bad, sort of speak, depending on how you act to influence the outcome, because lifestyle habits can influence gene expression, which is the study of epigenetics.

(Read my posts 9 Anti-aging Lifestyle Habits That Work (say 3 doctors), and Behavior and Epigenetics – The Surprising Reasons Your Kids Care About Your Genetics.)

If left unaltered, DNA methylation levels will decline as we age, resulting in many of the attributes of aging, including the onset of various chronic diseases, including cancer and neurodegenerative diseases such as Parkinson’s and Huntington’s.

Surely, you know people who look great for their age and are healthier than their same-age peers. Although there undoubtedly are many reasons for this, one big reason is that their DNA may be, in effect, younger than their chronological years.


Measure Your Biological Age via DNA Methylation

Increase DNA methylation

There are “methylation clocks”, sometimes called “epigenetic clocks” that are made up of specific sites of DNA where the DNA methylation levels can be measured.

These clocks have undergone extensive research, and have proven to be  a highly accurate way to measure age in humans. Soon, the information that will be gleaned from these “clocks” will point to individually optimized diets, supplements and exercise regimes; in fact, a test called Index touts that it can do just that.

Elysium Health (the company that makes the ever-popular NAD+ precursor called Basis) now has a test called Index, a novel, at-home test that tracks how fast you’ve been aging using the latest generation technology in the science of epigenetics.

Index tests your bioage

(Click image to learn about Index)

With Index you get:

  • Biological Age calculated, a measure of the average age at which your body is expected to function.
  • Cumulative Rate of Aging calculated, the pace at which your body has aged for every year you’ve been alive.
  • Science-backed lifestyle recommendations you can use to adopt healthier habits.

Although most of us would like to know if our biological age tracks our chronological age, or is higher or lower, the mirror along with your physical capabilities relative to when younger, provide a pretty good indication for how well your aging.

If you’re like most people I talk to about this subject, you’d like to be physically younger. (My biological age is 20 years lower according to this test developed by Dr. Steve Horvath, et al.)

So, let’s recap what I’ve just told you and then speak to what you can do to improve your DNA methylation, and thereby improve how well you age.

Increase DNA Methylation Recap:

  • DNA methylation is the process that controls how our DNA is expressed, in effect, by turning genes on and off.
  • DNA methylation levels decline as we age, which increases DNA damage, one primary factor behind aging.

Now is a good time to view Dr. Brad Stanfield’s video on this topic, and then examine the three ways you can increase DNA methylation.

Whether or not you take a test to find out your biological age, most of us want to perform better than we are now, assuming we’re much past 40 years old. If you want to stop your DNA methylation from declining over time, what can you do?


Three Ways To Increase DNA Methylation

The three ways you can improve your biological age that are supported by a considerable number of scientific studies are:

  1. Caloric restriction,
  2. Exercise, and
  3. TMG
1. Caloric Restriction

Currently, calorie restriction has been proven to be the most effective intervention that can extend the maximum lifespan and healthspan in a wide range of organisms, from tiny worms to monkeys.

Several independent studies compared the effect on DNA methylation when animals were put on a calorie restrictive diet, and reported that calorie restriction protects against age-related DNA methylation changes in mammals by stopping the DNA methylation decline in different tissue types, including the kidneys, liver and brain.

There is no current long-term human data to support these effects in humans; however, there is when it comes to exercise!

(Click here for some of my posts about caloric restriction)

2. Exercise

A meta-analysis of various studies found that resistance exercise combined with endurance training in humans caused positive changes in:

  • DNA methylation
  • Energy metabolism, and
  • Insulin sensitivity changes and pathways

(Click here for some of my posts about exercise.)

3. TMG

A 2015 study has shown that the availability of methyl group donors influences methylation levels. Our bodies have got a store of these methyl groups. For DNA methylation to happen we need these methyl groups, but these methyl groups are not just for DNA methylation — they’re also used to create neurotransmitters and antioxidants; therefore, we need to make sure that we’ve got enough of these methyl groups in our body to facilitate the DNA methylation process.

The best supplement to make this happen is TMG (trimethylglycine), also known as “betaine” (To learn the specifics as to why, go to timestamp 7:15 in the video above.) A meta-analysis showed that supplementation of TMG at four to six grams every day significantly lowers homocysteine levels, which then enables more methyl groups to be available for DNA methylation.

In addition to increasing methyl groups, lower homocysteine may lower your risk for developing vascular disease, heart attacks and cancer, says this 2010 study; however, it might just be that homocysteine is a marker for these diseases as opposed to directly influencing them.

If you decide to supplement with TMG/betaine at doses in excess of 1 gram, consider using a powder, such as Betaine Anhydrous Trimethylglycine offered by BulkSupplements. If your dose will be less than 1 gram, or you prefer capsules, consider NOW TMG, or Thorne Research Methyl-Guard-Plus.


Your Takeaway

Remember these four things:

  1. Your level of DNA methylation has a lot to do with how well you age (your biogage).
  2. DNA methylation naturally declines with age.
  3. You can test your bioage based on DNA methylation with an at-home test called Index, or less reliably (but at no cost) via an algorithm based on several blood markers.
  4. A good way to increase methyl groups and DNA methylation is to supplement with TMG.


Here are some resources for a deeper dive into this topic:

DNA Methylation and Its Basic Function

DNA methylation and healthy human aging

New findings showing how DNA methylation influences diseases

DNA methylation aging clocks: challenges and recommendations

Distinct DNA methylomes of newborns and centenarians

The Impact of Caloric Restriction on the Epigenetic Signatures of Aging

Epigenetic Modifications as Outcomes of Exercise Interventions Related to Specific Metabolic Alterations: A Systematic Review

The impact of dietary protein intake on longevity and metabolic health

Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults

Betaine supplementation decreases plasma homocysteine in healthy adult participants: a meta-analysis

Betaine in Inflammation: Mechanistic Aspects and Applications

Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: Meta-analysis of 8 randomized trials involving 37 485 individuals

Association of Plasma Concentration of Vitamin B12 With All-Cause Mortality in the General Population in the Netherlands


Last Updated on April 22, 2022 by Joe Garma

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Joe Garma

I help people live with more vitality and strength. I'm a big believer in sustainability, and am a bit nutty about optimizing my diet, supplements, hormones and exercise. To get exclusive Updates, tips and be on your way to a stronger, more youthful body, join my weekly Newsletter. You can also find me on LinkedIn, Twitter and Instagram.

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