The ProLon FMD — Get Better, Not Older

ProLong Fasting Mimicking Diet

ProLon FMD is a 5-day meal plan that tricks your body into thinking it’s fasting by deregulating the nutrient sensing mechanisms of the body. The results are worth the effort! Watch me do the program.

ProLong Fasting Mimicking Diet

The ProLon FMD (Fasting Mimicking Diet) is a meal plan that’s been made available to the public after years of clinical testing. It was only available by a doctor’s prescription, but now it’s ready for you.

This page contains everything you need to know about ProLon FMD — what it is, the science behind it, and videos of various people explaining the program in detail, including me doing the 5-day program, as well as my then 88 year-old mother.

IMPORTANT: Consult with your doctor before doing ProLon FMD if you are underweight, have health issues, or are taking medications.

Intro - Why do ProLon FMD?
Watch me do the ProLon FMD program (video)
The science behind ProLon FMD (video)
My Mom on ProLon (video)
Why ProLon is better than Caloric Restriction
Dr. Pompa interviews Dr. Kelly (video)
Body rejuvenation
ProLon FMD program


Intro – Why do ProLon FMD?

Although it’s called a “Fasting Mimicking Diet”, you don’t actually fast on the program.

“Fasting” is in the name not because of what you do — you actually eat on the program — but because of the health and anti-aging benefits derived from the ProLon FMD are the are same that occur when fasting… without the discomfort.

You get the advantages of a real fast, but without the strong pangs of hunger.

(Note: the links to the ProLon website where you can buy the FMD are affiliate links, which means the company pays me a fee. You pay the same amount either way should you buy the program. And by the way, all the profits he earns, by the way, go to the Create Cures Foundation whose mission is to help prevent illness and promote longer, healthier lives.)

I’ve followed the inventor of this fasting mimicking diet, Dr. Valter Longo, for five years now. Watched him being interviewed. Read his book. Spent the last several years experimenting with different types of caloric-restriction. And now I’m pleased to say that ProLon (the company he created) has accepted me as an affiliate, because I believe in the potential of fasting mimic diets to rejuvenate the body.

This is not a stretch. As you’ll soon see, the science shows that the Prolon Fasting Mimicking Diet rejuvenates specific biomarkers that express how well you’re aging. Or, actually, how well you’re not aging.

Among the dozens of interventions tested for anti-aging and health optimization, only one is currently incontrovertible — caloric restriction (“CR”). Twenty-plus year-long studies with monkeys, as well as many other organisms, have demonstrated that an approximate 30% daily restriction of calories provided by nutritious foods made the monkeys on CR much healthier and live longer than the group who ate at will.

The problem with sustained CR is that it makes people miserable, as it did the monkeys, but they had no choice. You do. You can get the same benefits of CR by simply spending five days a month a few months a year doing the ProLong Fasting Mimicking Program.

My mom did, and I videotaped her experience.


Watch Me Do the ProLon FMD Program

In the following videos, I take you through the meal plans ProLon FMD offers during the 5-day program, and how I managed my hunger, exercise and overall energy levels.

Day 1

The first day I cover:

  • What’s in the box
  • An overview of how to do the ProLon FMD program
  • My before-the-program weigh-in
  • How to prepare the first meal


Go here for the Dr. Valter Longo interview by Eleanor Sheekey.

Day 2

The second day I cover:

  • The difference in food mix between Day 1 and 2, as well as the rest of the program
  • The importance of eating mindfully, slowly, to allow yourself to feel fuller
  • What I do to mitigate hunger
  • Exercise snacks


The Summary Wrap-up

In this wrap-up I cover:

  • The hunger dilemma
  • Headaches
  • Energy levels
  • Bowel movements
  • Exercise
  • Weight loss
  • The reset


My posts about Autophagy


The Science Behind ProLon FMD

Watch biochemist Eleanor Sheekey from the Sheekey Science Show channel interview the inventor of the ProLon FMD, biogerontologist and cell biologist Dr. Valter Longo, explain the science behind ProLon FMD:


Click here to watch Eleanor's 2022 FMD update relevant for those with chronic health issues


Mom Does ProLon

I videotape my then 88 year-young mother doing her first five days of the ProLon Fasting Mimicking Diet, and briefly cover the science behind it:


Links mentioned in the video:

Keep going to learn about:

  • The alternative to sustained caloric restriction, which does work, but is painful;
  • Results of a clinical study on humans that proves the ProLon Fasting Mimicking Diet rejuvenates the body — even activating stem cells; and
  • What you can expect from spending 5 days on the Program for three consecutive months.


FMD — A (much!) Better Alternative to Caloric Restriction

ProLon Fasting Mimicking Diet

So why doesn’t everybody do CR? ProLon Fasting Mimicking Diet

Because we don’t want to live in misery!

But there is an alternative way of getting the benefits of daily CR without the pain. Yes, truly, one of the few examples where you don’t have to experience pain to gain. People who study such things refer to it as “caloric-mimicking” — something that has the same or similar benefits to CR, but via a different, more tolerable (even enjoyable) modality.

Scientists have experimented with various forms of restrictive eating to see which could have a favorable impact on healthspan (the years you’re healthy), and possibly lifespan as well, as measured by various biomarkers for things like systemic inflammation, blood sugar/insulin resistance, stem cell regeneration and lean muscle composition — all of which are severely affected as we age.

Tentative results show that restricted-eating might be a caloric-mimicking modality, but which one is best?

As I wrote in Choose Your Favorite Intermittent Fasting Protocol, there are many ways to skin this cat, such as fasting on only certain days of the week, reducing your “feeding window” each day (ie: eating only between noon and 8:00 PM) and periodic fasting (ie: one day per week, or three days per month).

Books have been written about each of these restricted-eating types of CR mimetics, but no study on them has been as robust and definitive as those with the monkeys, until recentlyDr. Valter Longo has led the charge in this area with his studies aiming at determining exactly what can produce the same or similar results as fasting or daily CR.

ProLong Fasting Mimicking Diet

Dr. Valter Longo

And he found it with his “Fasting Mimicking Diet” and the company — Prolon — that supplies the food that does the trick.

Dr. Valter Longo is the Director of both the Longevity Institute at the University of Southern California; The Program on Longevity and Cancer at IFOM in Milan; and the author of a book I recently devoured, The Longevity Diet.

He designed the Fasting Mimicking Diet after making a series of remarkable discoveries in humans that show how specific diets can activate stem cells and promote regeneration and rejuvenation in multiple organs to optimize health and offer anti-aging benefits.

Fasting Mimicking Diets Have Been Shown to Help:

  • Decrease Weight and Body Fat
  • Stem Cell Regeneration
  • Keep Glucose at Healthy Levels
  • Keep CRP at Healthy Levels
  • Keep Triglycerides at Healthy Levels
  • Keep Blood Pressure at Healthy Levels
  • Keep Healthy Levels of Bone Density
  • Impact in IGF-1 (Aging Marker)
  • Maintain Insulin Resistance at Healthy Levels
  • Maintain Cholesterol at Healthy Levels
  • Decrease Visceral Fat


What Food Does the Trick?  The ProLon Fasting Mimicking Diet, says Dr. Kelly

Prolong Fasting Mimicking Diet


The ProLon FMD is the only meal program that has gone through clinical trials. It’s also been patented for its anti-aging effects!

Watch the video interview and Q&A with Drs. David Pompa and James Kelly below. Dr. James Kelly describes the special foods offered by ProLon that trick your body into thinking it’s fasting and thereby deliver specific age-defying health benefits:


What Is the Trick?  Getting Your Body to Rejuvenate!

The trick is that the 5-day meal ProLon program provides scientifically researched micro- and macro-nutrients in precise quantities and combinations that nourish you, but are not recognized as food by your body. To be able to eat food while your body thinks you’re actually fasting is quite a trick!

Check out the results below  from the clinical study on the ProLon Fasting Mimicking Diet which examined substantially improved biomarkers for those who on the diet for 5 days each month for 3 months:

  • Insulin Growth Factor-1 (IGF-1) reduced by 14%
  • C-reactive Protein (CRP), a marker of systemic inflammation, reduced by 50%
  • Stem cell regeneration was stimulated
  • An average of five pounds of body fat, mostly abdominal fat, was lost
 Clinical Study Results
ProLon Fasting Mimicking Diet
ProLong Fasting Mimicking Diet

(click to enlarge)

Now, take a look how people with health issues benefited from the fasting diet (where you actually do eat) in only 5 days:

  • Obese people lost 9 pounds
  • Waistlines shrunk by about 3 centimeters (1.2 inches)
  • LDL (the so-called “bad” cholesterol) was reduced by 15 mg/dL
  • Triglycerides (the main part of body fat) was reduced by 25 mg/dL
  • Blood pressure dropped


Elevated Risk Cohort Results
ProLon Fasting Mimicking Diet
ProLong Fasting Mimicing Diet

(click to enlarge)

ProLon Fasting Mimicking Diet(Read the study here.)


The ProLon Fasting Mimicking Diet Program

ProLon Fasting Mimicking Diet

The ProLon FMD meal plan is followed 5 days per month. You can go back to your normal diet for the remaining 25 days of the month. This fasting-with-food meal plan is low in carbohydrates and proteins and has healthy fatty acids. The FMD patented recipe allows your body to stay under a fasting-like mode, which triggers a set of protection measures that the body has developed during natural selection when during times when food was scarce and not easy to find and store. This caused the body optimize its performance, rejuvenate its cells, and thrive under such circumstances, because if you didn’t take it up a notch when food was scarce, you’d soon be dead.


What Happens During The 5-Day Prolong Fasting Mimicking Diet?

ProLon Fasting Mimicking Diet

Here’s another way to envision it:

ProLon Fasting Mimicking Diet


Your Takeaway

If you can afford it, do yourself a favor and try the ProLon Fasting Mimicking Diet.

And I might add, you can’t afford not to try FMD if you’re overweight, have high blood sugar, high blood pressure, inflamed joints — or are simply aging poorly.


Go check it out!

A platoon of Navy Seals couldn’t make you do FMD?

Then at least check out how to do some type of intermittent fasting that I describe here. Because not only do we all need to eat less, but we also need to eat less often.


Last Updated on December 21, 2022 by Joe Garma

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Joe Garma

I help people live with more vitality and strength. I'm a big believer in sustainability, and am a bit nutty about optimizing my diet, supplements, hormones and exercise. To get exclusive Updates, tips and be on your way to a stronger, more youthful body, join my weekly Newsletter. You can also find me on LinkedIn, Twitter and Instagram.

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